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Steady-state concentrations are expected to be achieved within two days of dosing. According to a report by the FDA, Seroquel has a half-life of about six hours, and it is metabolized primarily through the liver. After 12 hours, one dose of Seroquel will be almost eliminated from the body. After 1.5 days, Seroquel will be metabolized entirely out of your system. According to a report by the FDA, Seroquel has a half-life of about six hours, and it is metabolized primarily through the liver. After 12 hours, one dose of Seroquel will be almost eliminated from the body. After 1.5 days, Seroquel will be metabolized entirely out of your system. How long does metoprolol stay in your system? Lab tests can detect metoprolol in the blood. The normal range for LabCorp metoprolol blood tests is 30−280 ng/mL; reference ranges for other testing laboratories may differ. At a half-life of 3 to 7 hours, metoprolol is out of the system in about one day. 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The dose was initially 25mg and rose over the year to 200mg which I rarely if ever took. In May 2016 I did a detox, on my own and at home for four weeks and came of the painkillers, I then decided it was time to get rid of the psychiatric...Jul 08, 2009 · Tamazipam has a long half life, which means a 10mg dose will stay in the system for between 20-30 hours. a 20mg dose 30-50 hours. a 25mg dose 40-60 hours ... and so on. hope this helps. Jan 31, 2010 · it takes 11 hours from the time that you toke seroquel to stop all defector's. but it does take 2 days for it to completely flush out of your body's system. but it does very from what mg you take. Seroquel stays in your system for an average of six days after you stop taking it. The half-life of a drug is the time it takes for your body to remove 50% of the drug. Seroquel has a half-life of 21 hours, so it takes six days for your body to remove 50% of the drug. 2. Answer (1 of 3): Seroquel stays in your system for a long time. I do not like to discontinue suddenly. I recommend my patients to discontinue slowly to prevent insomnia. cutting down to 1/2 pill every other day, then every day and finally 3 times a week only and twice a week before discontinuing.... I've been on 300 mg Lamictal for my bipolar disorder 2 and 50 mg seroquel as a sleep aid for the last 6 years and I honestly love it, no complaints whatsoever. There's no added weight gain, at least not for me, I sleep beautifully all night and I don't wake up hella groggy. 10/10 would recommend!Seroquel's maximum levels were observed 90 minutes after taking immediate-release tablets and 6 hours after taking extended-release pills. 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